Research

At HORMOBIOME, we aim to enhance global health by unlocking a deeper understanding of the complex interplay between hormones and the microbiome. We conduct cutting-edge research on critical areas such as infertility, autoimmune diseases, and aging, aiming to generate impactful, science-based solutions that benefit society.

Fertility

🔬 What We Study:
We explore how hormonal and microbiome imbalances in the reproductive and gastrointestinal tracts affect fertility in women with endometriosis. Our research focuses on identifying non-invasive biomarkers from the oral and gut microbiome to improve diagnosis and disease management.

🧪 Our Approach:
Using advanced metagenomics and metatranscriptomics, we analyze how hormonal imbalances shape microbial composition and how these interactions impact reproductive health. Our goal is to develop more precise and accessible diagnostic strategies for endometriosis-related infertility.

🎯 Why It Matters:
By understanding the microbiome-hormone connection, we aim to create non-invasive tools and personalized therapies to restore hormonal and microbial balance, optimizing fertility outcomes.

Menopause

🔬 What We Study:
Menopause is a critical stage in a woman’s life, marked by hormonal shifts and immune aging (immunosenescence), which impact the oral microbiome and overall health. The decline in estrogen levels and changes in salivary flow can lead to microbial imbalances and an increased risk of autoimmune diseases.

🧪 Our Approach:
We analyze microbial profiles in different oral habitats and their relationship with salivary estradiol levels to identify menopause-associated microbiome changes. Our research aims to uncover key microbial markers that could help in early detection and management of menopause-related health risks.

🎯 Why It Matters:
By understanding how hormonal and microbial shifts influence aging and immune health, we seek to develop preventive strategies that promote healthy aging and improve overall well-being in postmenopausal women.

Autoimmune Diseases

🔬 What We Study:
We investigate how hormones and microbiota influence the immune system in Sjögren’s syndrome (SS). Our goal is to understand how microbial changes contribute to disease progression and symptoms.

🧪 Our Approach:
We analyze bacteria and fungi in saliva from SS patients and healthy controls using advanced metagenomics and bioinformatics. By linking microbial communities to host immune factors, we aim to uncover new biomarkers and therapeutic targets.

🎯 Why It Matters:
By restoring hormonal and microbial balance, we hope to develop personalized treatments that improve immune function and patient outcomes.

State-of-the-Art Techniques

To drive advances in these focus areas, HORMOBIOME employs cutting-edge scientific methodologies, providing comprehensive insights into hormone-microbiome interactions.

We create advanced classification systems for hormone-microbiota interactions, organized by life stages (e.g., puberty, pregnancy, menopause), hormone types, and body locations (e.g., gut, skin, oral cavity). This framework offers researchers and clinicians a robust tool for conducting highly personalized research and developing therapeutic strategies.

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Hormonal-Microbial Interaction Mapping

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Multi-Omics Analysis

We utilize artificial intelligence and big data analytics to uncover complex patterns and predictive biomarkers in hormone-microbial interactions. This enables precision diagnostics and personalized therapies, leading to safer and more effective health outcomes.

AI-Driven Insights

Science connecting hormones, microbiota, and health

Research

State-of-the-Art Techniques

HORMOBIOME LAB