Science connecting hormones, microbiota, and health
HORMOBIOME leads the next era in hormone-microbiome research, defining how hormonal interactions with microbiota influence health outcomes. Our innovative discoveries are setting new standards in precision medicine, opening transformative paths for targeted diagnostics and personalized therapies.
Publications
Complete list HERE
Rus MJ, Sauco Carballo C, Faria FD, Simon-Soro A. Hormonal Environment Shapes the Oral Microbiome. Adv Exp Med Biol. (2025);1472:225-242. doi: 10.1007/978-3-031-79146-8_14
Nieto, M.R., Rus, M.J., Areal-Quecuty, V. et al. Menopausal shift on women’s health and microbial niches. npj Womens Health 3, 3 (2025). doi: 10.1038/s44294-024-00050-y
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Areal-Quecuty V, Cantiga-Silva C, Simón-Soro A, Cabanillas-Balsera D, Martín-González J, Saúco-Márquez JJ, Segura-Egea JJ. Apical periodontitis in osteoporotic postmenopausal women: Systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2024 Sep 1;29(5):e711-e718. doi: 10.4317/medoral.26697.
Marcos AT, Rus MJ, Areal-Quecuty V, Simon-Soro A, Navarro-Pando JM. Distinct Gastrointestinal and Reproductive Microbial Patterns in Female Holobiont of Infertility. Microorganisms. 2024 May 14;12(5):989. doi: 10.3390/microorganisms12050989.
Saúco C, Rus MJ, Nieto MR, Barros C, Cantiga-Silva C, Lendines-Cordero D, Calderer-Ortiz M, Zurita-García M, Arias-Herrera S, Monsalve-Guil L, Segura-Egea JJ, Simon-Soro A. Hyposalivation but not Sjögren's syndrome associated with microbial dysbiosis in women. Front Microbiol. 2023 Oct 6;14:1240891. doi: 10.3389/fmicb.2023.1240891.
Huang Y, Liu Y, Pandey NK, Shah S, Simon-Soro A, Hsu JC, Ren Z, Xiang Z, Kim D, Ito T, Oh MJ, Buckley C, Alawi F, Li Y, Smeets PJM, Boyer S, Zhao X, Joester D, Zero DT, Cormode DP, Koo H. Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention. Nat Commun. 2023 Sep 29;14(1):6087. doi: 10.1038/s41467-023-41687-8.
Bustos-Lobato L, Rus MJ, Saúco C, Simon-Soro A. Oral microbial biomap in the drought environment: Sjogren's syndrome. Mol Oral Microbiol. 2023 Oct;38(5):400-407. doi: 10.1111/omi.12435.
Xiang Z, Wakade RS, Ribeiro AA, Hu W, Bittinger K, Simon-Soro A, Kim D, Li J, Krysan DJ, Liu Y, Koo H. Human Tooth as a Fungal Niche: Candida albicans Traits in Dental Plaque Isolates. mBio. 2023 Feb 28;14(1):e0276922. doi: 10.1128/mbio.02769-22.
Negrini TC, Ren Z, Miao Y, Kim D, Simon-Soro Á, Liu Y, Koo H, Arthur RA. Dietary sugars modulate bacterial-fungal interactions in saliva and inter-kingdom biofilm formation on apatitic surface. Front Cell Infect Microbiol. 2022 Nov 9;12:993640. doi: 10.3389/fcimb.2022.993640.
Ren Z, Jeckel H, Simon-Soro A, Xiang Z, Liu Y, Cavalcanti IM, Xiao J, Tin NN, Hara A, Drescher K, Koo H. Interkingdom assemblages in human saliva display group-level surface mobility and disease-promoting emergent functions. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2209699119. doi: 10.1073/pnas.2209699119.
McGinniss JE, Whiteside SA, Deek RA, Simon-Soro A, Graham-Wooten J, Oyster M, Brown MD, Cantu E, Diamond JM, Li H, Christie JD, Bushman FD, Collman RG. The Lung Allograft Microbiome Associates with Pepsin, Inflammation, and Primary Graft Dysfunction. Am J Respir Crit Care Med. 2022 Dec 15;206(12):1508-1521. doi: 10.1164/rccm.202112-2786OC.
Simon-Soro A, Ren Z, Krom BP, Hoogenkamp MA, Cabello-Yeves PJ, Daniel SG, Bittinger K, Tomas I, Koo H, Mira A. Polymicrobial Aggregates in Human Saliva Build the Oral Biofilm. mBio. 2022 Feb 22;13(1):e0013122. doi: 10.1128/mbio.00131-22.
Angarita-Díaz MP, Simon-Soro A, Forero D, Balcázar F, Sarmiento L, Romero E, Mira A. Evaluation of possible biomarkers for caries risk in children 6 to 12 years of age. J Oral Microbiol. 2021 Aug 17;13(1):1956219. doi: 10.1080/20002297.2021.1956219.
McGinniss JE, Whiteside SA, Simon-Soro A, Diamond JM, Christie JD, Bushman FD, Collman RG. The lung microbiome in lung transplantation. J Heart Lung Transplant. 2021 Aug;40(8):733-744. doi: 10.1016/j.healun.2021.04.014.
Simon-Soro A, Kim D, Li Y, Liu Y, Ito T, Sims KR Jr, Benoit DSW, Bittinger K, Koo H. Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes. NPJ Biofilms Microbiomes. 2021 Jan 22;7(1):7. doi: 10.1038/s41522-020-00181-5.
Heimisdottir LH, Lin BM, Cho H, Orlenko A, Ribeiro AA, Simon-Soro A, Roach J, Shungin D, Ginnis J, Simancas-Pallares MA, Spangler HD, Zandoná AGF, Wright JT, Ramamoorthy P, Moore JH, Koo H, Wu D, Divaris K. Metabolomics Insights in Early Childhood Caries. J Dent Res. 2021 Jun;100(6):615-622. doi: 10.1177/0022034520982963.
Xiang Z, Koo H, Chen Q, Zhou X, Liu Y, Simon-Soro A. Potential implications of SARS-CoV-2 oral infection in the host microbiota. J Oral Microbiol. 2020 Nov 29;13(1):1853451. doi: 10.1080/20002297.2020.
Huang Y, Liu Y, Shah S, Kim D, Simon-Soro A, Ito T, Hajfathalian M, Li Y, Hsu JC, Nieves LM, Alawi F, Naha PC, Cormode DP, Koo H. Precision targeting of bacterial pathogen via bi-functional nanozyme activated by biofilm microenvironment. Biomaterials. 2021 Jan;268:120581. doi: 10.1016/j.biomaterials.2020.120581.
Simon-Soro A, Sohn MB, McGinniss JE, Imai I, Brown MC, Knecht VR, Bailey A, Clarke EL, Cantu E, Li H, Bittinger K, Diamond JM, Christie JD, Bushman FD, Collman RG. Upper Respiratory Dysbiosis with a Facultative-dominated Ecotype in Advanced Lung Disease and Dynamic Change after Lung Transplant. Ann Am Thorac Soc. 2019 Nov;16(11):1383-1391. doi: 10.1513/AnnalsATS.201904-299OC.
McGinniss JE, Imai I, Simon-Soro A, Brown MC, Knecht VR, Frye L, Ravindran PM, Dothard MI, Wadell DA, Sohn MB, Li H, Christie JD, Diamond JM, Haas AR, Lanfranco AR, DiBardino DM, Bushman FD, Collman RG. Molecular analysis of the endobronchial stent microbial biofilm reveals bacterial communities that associate with stent material and frequent fungal constituents. PLoS One. 2019 May 29;14(5):e0217306. doi: 10.1371/journal.pone.0217306.
McGinniss JE, Imai I, Simon-Soro A, Brown MC, Knecht VR, Frye L, Ravindran PM, Dothard MI, Wadell DA, Sohn MB, Li H, Christie JD, Diamond JM, Haas AR, Lanfranco AR, DiBardino DM, Bushman FD, Collman RG. Molecular analysis of the endobronchial stent microbial biofilm reveals bacterial communities that associate with stent material and frequent fungal constituents. PLoS One. 2019 May 29;14(5):e0217306. doi: 10.1371/journal.pone.0217306.
Naha PC, Liu Y, Hwang G, Huang Y, Gubara S, Jonnakuti V, Simon-Soro A, Kim D, Gao L, Koo H, Cormode DP. Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption. ACS Nano. 2019 May 28;13(5):4960-4971. doi: 10.1021/acsnano.8b08702.